Ethyl 2-chloro-5-fluoronicotinate

Ethyl 2-chloro-5-fluoronicotinate - Names and Identifiers

Name	Ethyl 2-chloro-5-fluoronicotinate
Synonyms	2-CHLORO-5-FLUORONICOTINI... Ethyl 2-chloro-5-fluoronicotinate Ethyl2-Chloro-5-fluoronicotinicacid 2-CHLORO-5-FLUORONICOTINIC ACID ETHYL ESTER 2-CHLORO-5-FLUORONICOTONIC ACID ETHYL ESTER ethyl 2-chloro-5-fluoropyridin-3-carboxylate ethyl 2-chloro-5-fluoropyridine-3-carboxylate Ethyl 2-chloro-5-fluoropyridine-3-carboxylate, 2-Chloro-3-(ethoxycarbonyl)-5-fluoropyridine
CAS	139911-30-1
InChI	InChI=1/C8H7ClFNO2/c1-2-13-8(12)6-3-5(10)4-11-7(6)9/h3-4H,2H2,1H3

Ethyl 2-chloro-5-fluoronicotinate - Physico-chemical Properties

Molecular Formula	C8H7ClFNO2
Molar Mass	203.6
Density	1.328g/cm³
Boling Point	252.7°C at 760 mmHg
Flash Point	106.6°C
Vapor Presure	0.0191mmHg at 25°C
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.507

Ethyl 2-chloro-5-fluoronicotinate - Introduction

Ethyl 2-chloro-5-fluoronicotinate is an organic compound with the chemical formula C8H6ClFO2.

Nature:
Ethyl 2-chloro-5-fluoronicotinate is a colorless liquid with a special smell. It has a density of about 1.37 g/mL and is almost insoluble in water at room temperature, but soluble in organic solvents such as ether and xylene.

Use:
Ethyl 2-chloro-5-fluoronicotinate is widely used in organic synthesis. It is often used as a reagent, catalyst and raw material, especially in the preparation of fluorine-containing compounds. Sometimes it can also be used in the synthesis of drugs and pigments.

Preparation Method:
The preparation of ethyl 2-chloro-5-fluoronicotinate can be achieved by reacting 2-bromo-5-fluoronicotinic acid with ethanol. First, 2-bromo-5-fluoronicotinic acid is reacted with ethanol under acidic conditions to obtain ethyl 2-chloro-5-fluoronicotinate. The reaction process requires attention to safety measures to prevent contact with the skin and respiratory tract.

Safety Information:
Ethyl 2-chloro-5-fluoronicotinate is an organic compound that is irritating and corrosive. Wear appropriate protective equipment such as gloves, glasses and protective clothing during use. Avoid direct contact with the skin and make sure to operate in a well-ventilated place to reduce the risk of inhaling vapors. During handling and storage, the safe handling of chemicals should be strictly followed and kept away from ignition sources and strong oxidants. In case of swallowing or accidental contact, seek medical attention immediately.

Last Update：2024-04-09 21:01:54